Is serum gamma-glutamyltransferase a misleading test?
نویسندگان
چکیده
منابع مشابه
Is serum gamma glutamyltransferase a marker of oxidative stress?
The primary role of cellular gamma glutamyltransferase (GGT) is to metabolize extracellular reduced glutathione (GSH), allowing for precursor amino acids to be assimilated and reutilized for intracellular GSH synthesis. Paradoxically, recent experimental studies indicate that cellular GGT may also be involved in the generation of reactive oxygen species in the presence of iron or other transiti...
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Elevated levels of serum gamma-glutamyltransferase (GGT) levels have been found to predict the development of type 2 diabetes in adults. The role of GGT in insulin resistance (IR) among children is largely unknown. We investigated whether GGT among hepatic enzymes is independently associated with IR in obese Korean children. A total of 1308 overweight (above the 85th BMI percentile of Korean re...
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A meta-analysis of 10 prospective cohort studies,1 including our own,2 reported that serum -glutamyltransferase (GGT) predicted incident vascular events. This metaanalysis posed one important, but unsolved question: why does serum GGT predict incident vascular events? In addition to vascular events, serum GGT predicts various important clinical outcomes including type 2 diabetes, metabolic synd...
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BACKGROUND Serum γ - glutamyltransferase (GGT) is implicated in the pathogenesis of endothelial dysfunction and atherosclerosis. Albuminuria is a marker of endothelial damage and correlated with structural and functional integrity of the vasculature. Our objective was to evaluate the association between serum GGT level and prevalence of albuminuria in a Chinese population. MATERIALS AND METHO...
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OBJECTIVES Accumulating data indicate that serum gamma-glutamyltransferase (GGT) activity represents a true marker of atherosclerotic cardiovascular disease and has prognostic importance. In this study, we sought to evaluate serum GGT activity in patients with metabolic syndrome (MetS). STUDY DESIGN We enrolled 232 patients (mean age 60.4 years) from our outpatient cardiology clinic, 117 with...
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ژورنال
عنوان ژورنال: BMJ
سال: 1983
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.286.6364.531